The CVODESolver plugin uses CVODE to solve ODEs and it can be customised through the following properties:

The default settings should work with most models. However, some models may require some minor adjustments. This is the case with cardiac cellular electrophysiological models that need a stimulus protocol to generate an action potential. Such a protocol is likely to be ignored by CVODE, if Maximum step and Interpolate solution are set to their default values of 0 and True, respectively. To address this issue, you can either set Maximum step to the length of the stimulus protocol or set Interpolate solution to False. The former approach will yield (slightly) less accurate results, but they will be obtained (much) faster.